Estraval Depot Injection contains estradiol valerate, a form of estrogen used in hormone replacement therapy (HRT). Estradiol is the primary female sex hormone produced by the ovaries. In menopausal women, estradiol levels decline, leading to symptoms such as hot flashes, night sweats, vaginal dryness, and mood changes. Estradiol valerate injection delivers the hormone intramuscularly for gradual release, helping to alleviate menopausal symptoms and prevent osteoporosis. It may also be used as part of feminizing hormone therapy for transgender women or to treat hypoestrogenism due to ovarian failure.

Estraval Depot should be administered by a healthcare professional. The usual dose varies depending on the indication but is typically injected deep into the muscle of the buttock every four weeks. Your doctor will determine the correct dosage and schedule based on your symptoms and hormone levels. Do not self-administer or adjust the dosing interval without medical guidance. While using Estraval Depot Injection, your doctor may monitor blood pressure, liver function and breast/pelvic health. Inform them of any vaginal bleeding, severe headaches or leg swelling.

Common side effects include breast tenderness, headache, nausea, fluid retention, and mild weight changes. These may subside as your body adjusts. Serious but rare risks include blood clots, stroke, heart attack, gallbladder disease, and breast or uterine cancer. Smoking, obesity and advanced age can increase these risks. Estrogen therapy should be used at the lowest effective dose for the shortest duration consistent with treatment goals. Tell your doctor if you have a history of hormone-dependent cancer, blood clots, liver disease, or if you are pregnant. Estradiol injections may interact with thyroid hormones, corticosteroids, and certain anticonvulsants; disclose all medications and supplements. Regular follow-up visits and screenings are important to maintain safety while on Estraval Depot therapy.